Revelation 16:10

Angel - Messenger.

Vial - Bowl; goblet.

The seat of the beast - Επι τον θρονον του θηριου· Upon the throne of the wild beast. The regal family was smitten by the fourth vial; they did not repent: then the fifth angel pours out his vial on the throne of the wild beast, or antichristian idolatrous power.

Was full of darkness - Confusion, dismay, and distress.

And the fifth angel poured out his vial upon the seat of the beast - The previous judgments had been preparatory to this. They all had a bearing on this, and were all preliminary to it; but the "seat" - the home, the center of the power of the beast - had not yet been reached. Here, however, there was a direct blow aimed at that power, still not such yet as to secure its final overthrow, for that is reserved for the pouring out of the last vial, Revelation 16:17-21. All that is represented here is a heavy judgment which was merely preliminary to to that final overthrow, but which affected the very seat of the beast. The phrase "the seat of the beast" - τὸν θρόνον τοῦ θηρίου ton thronon tou thēriou - means the "seat" or "throne" which the representative of that power occupied, the central point of the Anti-christian dominion. Compare the notes on Revelation 13:2. See also Revelation 2:13. I understand this as referring to the very seat of the papal power - Rome - the Vatican.

And his kingdom was full of darkness - Confusion - disorder - distress, for darkness is often the emblem of calamity, Isaiah 59:9-10; Jeremiah 13:16; Ezekiel 30:18; Ezekiel 32:7-8; Ezekiel 34:12; Joel 2:2.

And they gnawed their tongues for pain - This is a "most significant expression of the writhings of anguish." The word rendered here "gnawed" does not occur elsewhere in the New Testament, nor is the expression elsewhere used in the Bible; but its meaning is plain - it indicates deep anguish.

16:10 The four first phials are closely connected together; the fifth concerns the throne of the beast, the sixth the Mahometans, the seventh chiefly the heathens. The four first phials and the four first trumpets go round the whole earth; the three last phials and the three last trumpets go lengthways over the earth in a straight line. The fifth poured out his phial upon the throne of the wild beast - It is not said, "on the beast and his throne." Perhaps the sea will then be vacant. And his kingdom was darkened - With a lasting, not a transient, darkness. However the beast as yet has his kingdom. Afterward the woman sits upon the beast. and then it is said, "The wild beast is not," Revelation 17:3 ,7,8.